Offre de thèse – PhD 4D-E Biocell (“4D microporous and electrostimulable scaffold as innovative cell culture platform”)

Non classé

CY Cergy Paris Université, Labs of I-MAT :
LPPI : https://www.cyu.fr/cy-lppi-laboratoire-de-physicochimie-des-polymeres-et-des-interfaces
ERRMECe : https://errmece.u-cergy.fr/

The PhD project is to develop a 4D microporous and electrostimulable scaffold as innovative cell
culture platform that will combine controlled biochemical, topographical, mechanical and electrical
cues, along with tunable actuation. This smart and electro-responsive 4D-cell culture scaffold aims at
recapitulating in vitro the diversity and dynamic of in vivo signals, which physio/pathologically regulate
cells’ behavior. To better mimic the native cells’ biological living 4D-environment, the development of
relevant in vitro cell culture platform is a long-standing challenge with perspectives in advanced cell
biology, drug screening and tissue engineering. To date promising in vitro 3D-porous polyHIPE-based
scaffolds are developed. The emergence of electronic conducting polymers (ECPs) is of interest to turn
synthetic scaffolds from passive to active conducting scaffolds. Additionally, conducting polymers can
provide electromechanical dynamic (volume, stiffness, force…) when reversibly switched from
oxidized to reduced states, using low electrochemical potentials (~ 1V). This uncommon behavior of
ECPs makes possible the development of materials with controllable volume/pore size changes, adding a 4th dimension to 3D scaffolds and allowing theoretically both electrical and mechanical
stimulations during cell culture.

Candidate Profile

  • Master degree graduated in biology / biochemistry / biomaterials /chemistry with a strong scientific
    interest on material chemistry and multidisciplinary approaches.
  • Skills in cell culture, imagery acquisition and analysis, and material synthesis.
  • A high level of scientific English and correct expression/writing.
  • Curiosity, autonomy, rigor and capacity to work within multidisciplinary team are required.

Starting date, duration, funding

Starting from Autumn 2021, for a duration of 36 months.

Funding : Respore (https://www.respore.fr/)

Localization and Supervision :

The thesis student will participate in the Respore funded project 4D-eBioCell under the supervision of
C. Plesse, HDR, A. Ferrandez-Montero, C. Vancaeyzeele (LPPI) J. Leroy-Dudal & R. Agniel
(ERRMECe).

She/ he will be integrated into LPPI/ERRMECE/I-MAT units– CY Paris Cergy University.
The student will benefit from the experience of the host teams and will interact with post-docs and other students in the groups to carry PhD in a highly dynamic and stimulating environment.

Application – Deadline June 01st 6.00 PM.

Send a complete CV and a letter of motivation to (in a unique pdf file named
“Application4DeBioCell2021-NAME”) : remy.agniel@cyu.fr

For more information: Download here PhD-proposal-4DEBioCellDownload